产品货号：
Z35719
中文名称：
Perforin/PRF1抗体
英文名称：
Anti-Perforin/PRF1 Antibody (Clone#CE2.10)
产品规格：
100μg(vial)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Perforin/PRF1 Antibody (Clone#CE2.10) |
| 指标别名 | Cytolysin;FLH2;HPLH2;P1;Perforin;Perforin 1;PFN1;PFP;PRF1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | IP,WB |
| 基因名称 | Prf1 |
| 克隆号 | CE2.10 |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant mouse perforin (aa 98-534). |
| 计算分子量 | 62kDa |
| 成分 | Each vial contains 0.02% sodium azide. |
| 浓度 | 0.5～1mg/mL,actual concentration vary by lot.Use suggested dilution ratio to decide dilution procedure. |
| 产品形态 | 溶液 |
| 背景资料 | PRF1,also known as Perforin-1,is a protein that in humans is encoded by the PRF1 gene.It is mapped to 10q22.1.PRF1 is a cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells.Upon degranulation,PRF1 inserts itself into the target cell's plasma membrane,forming a pore.The lytic membrane-inserting part of perforin is the MACPF domain.This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.PRF1 has structural and functional similarities to complement component 9 (C9).Like C9,this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells.This protein is one of the main cytolytic proteins of cytolytic granules,and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.PRF1 is thought to act by creating holes in the plasma membrane which triggers an influx of calcium and initiates membrane repair mechanisms.These repair mechanisms bring perforin and granzymes into early endosomes. |
| Uniprot ID | P10820 |
| 基因名全称 | Perforin-1 |
| 蛋白名全称 | Perforin-1 (Prf1) |
相关搜索：Perforin/PRF1抗体，Perforin抗体，PRF1单抗，Anti-Perforin/PRF1 Antibody (Clone#CE2.10)